Twitter Digest for October 14, 2019

Spotlight on Limb dystonia

Limb dystonia is a type of dystonia consisting of involuntary contractions of the arms or legs associated with abnormal posturing, repetitive movements, and functional impairment. Limb dystonia is classified as primary if dystonia is the only presenting symptom or as secondary if associated with additional neurologic signs and an underlying cause is identified or suspected. Writer’s cramp is the most common task-specific upper limb dystonia. Limb dystonia may be the initial presenting sign in neurodegenerative disorders like Parkinson disease, progressive supranuclear palsy, and corticobasal ganglionic degeneration.

In this article, Dr. Corneliu Luca and Dr. Carlos Singer of the University of Miami review current knowledge on limb dystonias. They review updates on the classification, genetics, and pathophysiology of limb dystonia. The main clinical features of limb dystonia together with advances in the etiology, pathogenesis, and treatment of limb dystonia are also reviewed.

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Twitter Digest for October 11, 2019

Twitter Digest for October 10, 2019

Spotlight on Early myoclonic encephalopathy

Early myoclonic encephalopathy is an epileptic encephalopathy syndrome with onset either in the neonatal period or within the first 3 months of life, characterized by erratic, fragmentary, or massive myoclonus, focal seizures, and late tonic spasms. The prognosis is severe. Early myoclonic encephalopathy and Ohtahara syndrome together are recognized as 2 of the epileptic encephalopathies seen in early infancy and characterized by suppression burst on electroencephalogram.

In this updated article, Dr. Jules Beal of Weill Cornell Medicine and New York-Presbyterian Queens Hospital and Dr. Solomon Moshé of Albert Einstein College of Medicine review the clinical and neurophysiological data, management, and etiologic factors. Early myoclonic encephalopathy is believed to have various prenatal etiologies that often remain unknown; inborn errors of metabolism and genetic disorders are sometimes found.

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Twitter Digest for October 9, 2019

Twitter Digest for October 7, 2019

Spotlight on Headache in transplant patients

In this article, discusses the approach to headache when presenting in the context of solid organ or hematopoietic stem cell transplant patients, which can include both primary and secondary causes. In this article, Dr. Jeniffer Robblee of Barrow Neurological Institute outlines the epidemiology and etiologies of headache in the transplant population including pharmacotherapies, infection, vascular associations, and miscellaneous causes. Suggestions for management and possible pathophysiological mechanisms are discussed.

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Twitter Digest for October 4, 2019