Twitter Digest for October 19, 2018

Twitter Digest for October 18, 2018

Twitter Digest for October 17, 2018

Twitter Digest for October 16, 2018

Twitter Digest for October 15, 2018

Spotlight on Split cord malformation

Split cord malformations, although rare, can cause progressive neurologic impairment if not properly identified and surgically treated. These malformations can be associated with tethered cord, congenital scoliosis, and other spinal dysraphisms. In this article, Dr. Stephen Nelson of Tulane University School of Medicine and Brittany Gerstein of Tulane University describes the various signs and symptoms that are associated with these malformations, the imaging modalities best used for diagnosis, and the surgical treatment options and prognosis. They also provide updated information about the etiology, evaluation, and treatment of this interesting group of disorders.

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Twitter Digest for October 12, 2018

Twitter Digest for October 11, 2018

Spotlight on Septo-optic-pituitary dysplasia complex

In this article, Dr. Harvey Sarnat of the University of Calgary reviews the clinical, imaging, and neuropathological features and proposed pathogeneses of septo-optic-pituitary dysplasia complex and includes an extensive discussion of the genetic and acquired factors appearing to contribute to this disorder.

Although relatively rare, septo-optic-pituitary dysplasia complex is a highly relevant topic for pediatric neurologists, ophthalmologists, and pediatricians as the identification of visual impairment due to optic nerve hypoplasia requires the physician to consider the possibility of congenital hypopituitarism, a disorder that may be life-threatening if undetected and untreated.

This update includes a review of a study in which intraperitoneal injections of ethanol to pregnant mice heterozygous for a Sonic hedgehog-related gene at embryonic day 8 resulted in the development of optic nerve hypoplasia in the offspring. The results of this work lend support to the notion that ethanol consumption during the first trimester in humans may play a direct role in the pathogenesis of some cases of septo-optic-pituitary dysplasia complex rather than simply representing a casual associative phenomenon.

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Twitter Digest for October 10, 2018