Twitter Digest for September 16, 2019

Twitter Digest for September 13, 2019

Twitter Digest for September 12, 2019

Spotlight on Drug-induced parkinsonism

Despite the development of atypical antipsychotic drugs, parkinsonism is still a common problem among patients treated with these drugs as well as with antiemetics. Because drug-induced parkinsonism frequently produces disability in the elderly, it has replaced tardive dyskinesia as the most significant neurologic complication of antipsychotic drugs in the elderly, increasing the risk of falls and institutionalization. Despite the FDA’s concern about increased mortality with these drugs, carried in a “black box warning,” these drugs are widely used in the elderly, particularly in nursing homes. Aripiprazole is one of the most commonly prescribed drug in the United States, and other neuroleptics are also used in treating major depression and depression in bipolar disorder. Distinguishing purely drug-induced parkinsonism from idiopathic Parkinson disease is often clinically impossible.

In this article, Dr. Joseph Friedman of the Alpert Medical School of Brown University and University of Rhode Island discusses phenomenology, pathophysiology, diagnosis, and treatment.

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Twitter Digest for September 11, 2019

Twitter Digest for September 10, 2019

Twitter Digest for September 9, 2019

Spotlight on Sarcoid neuropathy

Sarcoidosis can involve the peripheral nervous system in a variety of ways. Patients can have a motor, sensory, sensorimotor, or autonomic neuropathy; the neuropathy may be primarily axonal or demyelinating. Patients can have involvement of isolated peripheral nerves, such as an ulnar neuropathy, or generalized involvement. Sarcoidosis is associated with virtually all peripheral neuropathy subtypes, eg, large fiber sensorimotor, pure motor, etc.

In this article, Dr. Jinny Tavee of Northwestern University Feinberg School of Medicine reviews current concepts of sarcoidosis-associated neuropathies. Clinical features, diagnostic considerations, and management strategies are discussed. In particular, the recent literature on sarcoidosis-associated small fiber neuropathy and possible new target-directed treatment options are highlighted. Concepts regarding the use of immunomodulatory agents are also highlighted.

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Twitter Digest for September 6, 2019

Twitter Digest for September 5, 2019