Spotlight on Headache associated with acute substance use or exposure

Substance headache is a headache that develops de novo with the use or exposure of a substance. The clinical manifestations of substance-induced headache are variable. In this article, Dr. Marta Torres-Ferrus, Dr. Edoardo Caronna, and Patricia Pozo-Rosich of Vall d’Hebron University Hospital and Headache Research Group, VHIR in Barcelona update the current evidence regarding the clinical manifestations and pathophysiology of headache associated with the acute use or exposure of certain substances, with specific focus on nitric oxide donor, and carbon monoxide and calcitonin gene-related peptide, which provides a better understanding of headache biology.

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