Spotlight on Vitamin B12 deficiency

B12 deficiency may cause an extraordinary variety of progressive neurologic syndromes. In this article, Dr. Ryan Jacobson of Loyola University Chicago Stritch School of Medicine describes the well-established manifestations of B12 deficiency as well as more controversial associations with macular degeneration, cerebrovascular disease, and dementia. In addition, although severe B12 deficiency has long been known to cause severe developmental delay, this update includes emerging information suggesting that a relative B12 deficiency may cause a common metabolic syndrome in infancy that is potentially linked to subtle developmental problems.

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