Twitter Digest for April 13, 2017

Spotlight on Congenital cytomegalovirus

Cytomegalovirus (CMV) is a ubiquitous agent responsible for most intrauterine infections. Besides well-known symptoms and findings such as hearing loss and microcephaly, congenital cytomegalovirus infection can also underlie certain cerebral anomalies and static leukodystrophies.

In this article, Dr. Elena Grebenciucova and Dr. Raymond Roos of the University of Chicago discuss uncommon presentations of asymptomatic congenital cytomegalovirus, predicted outcomes of congenital multi-strain cytomegalovirus infection, and updates on potential cytomegalovirus vaccines.

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Spotlight on Cerebral amyloid angiopathy

Cerebral amyloid angiopathy is increasingly recognized as a major cause of hemorrhagic stroke in the elderly as well as an important contributor to the growing challenge of vascular cognitive impairment, even in cerebral amyloid angiopathy patients without hemorrhagic stroke.

In this update, Dr. Anand Viswanthan and Dr. Steven Greenberg of Harvard Medical School highlight: (1) the importance of sulcal bleeding events in early recurrent hemorrhagic stroke in cerebral amyloid angiopathy; (2) the varied clinical presentations and associated neuroimaging profiles of the disease; (3) the cognitive profile of cerebral amyloid angiopathy; (4) the cumulative importance of different pathologic lesions in cerebral amyloid angiopathy that contribute to cognitive decline and the emergence of techniques to measure this cumulative effect by assessing structural connectivity in the disease; (5) the role of impaired vascular reactivity early in disease course; and (6) the role of vascular amyloid in causing cerebral microbleeds in the disease.

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Twitter Digest for April 7, 2017

Twitter Digest for April 6, 2017

Spotlight on Idiopathic hypersomnia

In this article, Dr. Logan Schneider of Stanford University School of Medicine discusses idiopathic hypersomnia, which is characterized by excessive daytime sleepiness, difficulty awakening (sleep drunkenness), and undisturbed overnight sleep without cataplexy or known cause of excessive sleepiness. Excessive sleepiness (hypersomnolence) of unknown etiology, which cannot be explained by another disorder, would be considered idiopathic hypersomnia. This should be clearly distinguished from other disorders that could present with complaints of excessive daytime sleepiness, such as narcolepsy, behaviorally-induced insufficient sleep, circadian rhythm disturbance, obstructive sleep apnea, or from hypersomnolence secondary to a medical condition or medication.

Patients with idiopathic hypersomnia frequently present in adolescence and may have symptoms of autonomic nervous system dysregulation, but they are most often affected because of inability to attend to daytime obligations such as school or work.

Because the pathophysiology is unknown, management is limited to symptomatic treatment and education.

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Twitter Digest for April 5, 2017

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Twitter Digest for April 3, 2017