Spotlight on Cerebral amyloid angiopathy

Cerebral amyloid angiopathy is increasingly recognized as a major cause of hemorrhagic stroke in the elderly as well as an important contributor to the growing challenge of vascular cognitive impairment, even in cerebral amyloid angiopathy patients without hemorrhagic stroke.

In this update, Dr. Anand Viswanthan and Dr. Steven Greenberg of Harvard Medical School highlight: (1) the importance of sulcal bleeding events in early recurrent hemorrhagic stroke in cerebral amyloid angiopathy; (2) the varied clinical presentations and associated neuroimaging profiles of the disease; (3) the cognitive profile of cerebral amyloid angiopathy; (4) the cumulative importance of different pathologic lesions in cerebral amyloid angiopathy that contribute to cognitive decline and the emergence of techniques to measure this cumulative effect by assessing structural connectivity in the disease; (5) the role of impaired vascular reactivity early in disease course; and (6) the role of vascular amyloid in causing cerebral microbleeds in the disease.

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