Spotlight on Fetal alcohol syndrome

Fetal alcohol syndrome is the most common preventable cause of intellectual disability in the Western world. In addition to inducing developmental delay, gestational alcohol exposure can lead to a variety of neurodevelopmental abnormalities, including epilepsy, attention deficit hyperactivity disorder, and academic difficulties. Many of these behavioral deficits in children with fetal alcohol syndrome are due to alcohol-induced neuronal death. In this updated clinical summary, Dr. Nancy Bonthius and Dr. Daniel Bonthius, both of the University of Iowa, discuss the diagnostic approach to fetal alcohol syndrome and recent research investigating the pathogenesis of alcohol-induced fetal damage. In addition, the authors discuss the importance of genetics in determining the vulnerability of the fetus to alcohol-induced brain damage. The authors also discuss some challenging medical-legal issues facing physicians and other caregivers that care for women who may abuse alcohol during pregnancy.

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MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.

Spotlight on Developmental delay in children: evaluation and management

Drs. Vera Joanna Burton and Siddharth Srivastava of the Kennedy Krieger Institute and the Johns Hopkins University School of Medicine explain methods for the identification and evaluation of delayed development in children. This clinical summary reviews core principles of development in children. Evaluation methods aimed at the identification of developmental problems in primary care and specialty care are discussed. The specialty medical evaluation and management of children with identified developmental disorders are reviewed, including recent recommendations about genetic testing.

To view the complete clinical summary, click here.

MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.

Spotlight on Congenital disorders of glycosylation

The congenital disorders of glycosylation constitute a rapidly expanding group of inherited disorders in which most patients suffer from neurologic symptoms including psychomotor developmental delay, cerebellar hypoplasia, retinopathy, epilepsy, and peripheral neuropathy. Patient presentations can demonstrate significant differences between and within the different subgroups. In this clinical summary, Dr. Erik Eklund of The Pediatric Institution, Lund University, explains the basic genetic and biochemical background to these syndromes and describes the most common subtypes in terms of initial clinical signs, diagnostic work-up, prognosis and clinical progression, and, in a few instances, treatment.

To view the complete clinical summary, click here.

MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.