Spotlight on Hypercoagulable states and cerebrovascular disease

In this article,Dr. Kathryn Kirchoff-Torres of Albert Einstein College of Medicine discusses advances in understanding the epidemiology, pathophysiology, and management of patients with ischemic stroke and cerebral venous thrombosis associated with genetic and acquired thrombophilia. This article also provides an overview of recently published treatment guidelines for patients with cerebrovascular events and thrombophilias, including the antiphospholipid antibody syndrome.

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MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.

Spotlight on Medical complications of stroke

Medical complications following stroke account for significant morbidity and mortality. These clinical conditions need to be recognized and managed effectively for a more favorable outcome. Direct effects of ischemic stroke, like hemorrhagic conversion or cerebral edema, account for the majority of deaths within the first week, but other medical complications that include cardiac causes (arrhythmias, myocardial infarction), infections (pneumonia, urosepsis), and venous thromboembolism account for at least 50% of mortality thereafter. In this clinical summary, Dr. Adrian Marchidann of SUNY Downstate Health Science Center discusses the medical complications of stroke-related deficits, their workup, and treatment modalities. Venous thromboembolism care information was updated according to the 9th edition of the American College of Chest Physicians guidelines.

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MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.

Spotlight on CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant genetic disease that induces recurrent subcortical ischemic strokes and ultimately leads to severe disability and death. In this update, Dr. Nancy Bonthius and Dr. Daniel Bonthius, both from the University of Iowa, describe the clinical presentation and natural history of CADASIL. In addition, they summarize the substantial progress that has recently been made toward understanding the mechanism of the disease in which a mutated gene encoding a transmembrane receptor leads to small vessel pathology within the brain.

To view the complete clinical summary, click here.

MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.

Spotlight on Headache associated with ischemic cerebrovascular disease

Headache often accompanies acute ischemic stroke. Observational studies indicate that 15% to 40% of patients with acute ischemic stroke report headache in close temporal relation to the event. The onset headache is more often seen in posterior circulation strokes than in strokes in other vascular territories. The pathophysiology of headache associated with acute ischemic stroke includes edema, hemorrhagic transformation, and changes in the trigeminovascular system. In this clinical summary, Dr. Hans-Christoph Diener of the University of Essen discusses headache associated with ichemic cerebrovascular disease.

To view the complete clinical summary, click here.

MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.

Spotlight on Ischemic stroke

Stroke is the leading cause of serious long-term disability in the United States and the fourth leading cause of death. Nearly 90% of all strokes are of the ischemic variety. In this clinical summary, Dr. Brian Silver of the Warren Alpert Medical School of Brown University reviews the history, clinical manifestations, risk factors, and pathology of ischemic stroke. Readers will learn about the important advances made in diagnosis, acute treatment, and prevention of stroke. Readers will also learn about advancements in recovery from stroke.

To view the complete clinical summary, click here.

MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.