Spotlight on Acute drug-induced movement disorders

Although it is generally believed that drug-induced movement disorders are much less common in the era of atypical antipsychotic drugs, there are little data to support this contention. Both acute and nonacute extrapyramidal disorders still do occur, so neurologists and psychiatrists should be able to recognize and treat them. Akathisia may be mistaken for other conditions, including restless legs, increased psychosis, or anxiety. These problems are occasionally seen with antiemetics and, more commonly, with antipsychotics (eg, chlorpromazine) used for migraines or depression. Akathisia may also be seen with tetrabenazine, a monoamine-depleting drug approved for the treatment of chorea associated with Huntington disease but also used for other hyperkinetic movement disorders. Although this drug does not cause tardive dyskinesia, it has been associated with acute dystonic reaction. Acute dystonic reactions occur with some, but not all, of the newer antipsychotic medications. Acute akathisia is harder to characterize because of the subjective nature of the symptoms. Neuroleptic malignant syndrome occurs with all antipsychotics, including all the atypicals.

In this article, Dr. Friedman of the Alpert Medical School of Brown University and University of Rhode Island, and Director of the Movement Disorders Program of Butler Hospital discusses acute drug-induced movement disorders.

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Spotlight on Acute drug-induced movement disorders

The term “acute drug-induced movement disorders” refers primarily to acute dystonic reactions and akathisia. Although it is generally believed that drug-induced movement disorders are much less common in the era of atypical antipsychotic drugs, there is little data to support this contention. Both acute and nonacute extrapyramidal disorders do still occur, so neurologists and psychiatrists should be able to recognize and treat them. In this clinical summary, Dr. Joseph Friedman of the Alpert Medical School of Brown University discusses the extrapyramidal side effects seen with all first generation, and most second generation, antipsychotic drugs and how akathisia may be mistaken for other conditions, including restless legs, increased psychosis, or anxiety.

To view the complete clinical summary, click here.

MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.

Spotlight on Neuro-ophthalmology of movement disorders

In this clinical summary, Dr. Olga Waln and Dr. Joseph Jankovic, both of Baylor College of Medicine, review neuro-ophthalmologic manifestations of the most common movement disorders, including Parkinson disease and atypical parkinsonism, dystonia, Huntington disease, Tourette syndrome, cerebellar disorders, and psychogenic and pediatric movement disorders. This summary discusses phenomenology, pathophysiology, and management of the ocular symptoms that can be encountered in patients with movement disorders.

To view the complete clinical summary, click here.

MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.

Spotlight on Deep brain stimulation in movement disorders

Deep brain stimulation is a FDA-approved therapy for Parkinson disease, tremor, and dystonia. The goal of deep brain stimulation is to improve quality of life and improve ability to function. In this clinical suymmary, Drs. Vikas Kotagal, Parag Patil, and Kelvin Chou of the University of Michigan provide a basic review of deep brain stimulation in movement disorders. They address patient selection, surgical procedure, programming, and postoperative medical management as well as clinical outcomes and prognosis of deep brain stimulation.

To view the complete clinical summary, click here.

MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.