Spotlight on Korsakoff syndrome

In this clinical summary, Dr. Alfredo Ardila of Florida International University discusses Korsakoff syndrome, which is marked by remote memory impairment together with characteristic profound anterograde memory deficits. Korsakoff syndrome is directly linked to a deficiency of thiamine. It is most commonly associated with chronic alcohol abuse. Korsakoff syndrome has also been described in the context of a number of other disorders that cause malnutrition or malabsorption. Head traumas with bilateral lesions of the limbic circuit may result in a memory disorder similar to the Korsakoff disease but frequently referred as of “Korsakowian syndrome” or “mental syndrome of Korsakoff.” Amnesia in Korsakoff syndrome could be the expression of damage to an extended brain memory system. An inherited insensitivity to thiamine has been proposed as a risk factor for alcoholism and Wernicke-Korsakoff syndrome. Successful treatment is infrequent and memory impairment may remain stable.

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MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.

Spotlight on Korsakoff syndrome

In this clinical summary, Dr. Alfredo Ardila of Florida International University discusses Korsakoff syndrome, which is marked by remote memory impairment together with characteristic profound anterograde memory deficits. Korsakoff syndrome is directly linked to a deficiency of thiamine. It is most commonly associated with chronic alcohol abuse. Korsakoff syndrome has also been described in the context of a number of other disorders that cause malnutrition or malabsorption. Head traumas with bilateral lesions of the limbic circuit may result in a memory disorder similar to the Korsakoff disease but frequently referred as of “Korsakowian syndrome” or “mental syndrome of Korsakoff.” Amnesia in Korsakoff syndrome could be the expression of damage to an extended brain memory system. An inherited insensitivity to thiamine has been proposed as a risk factor for alcoholism and Wernicke-Korsakoff syndrome. Successful treatment is infrequent and memory impairment may remain stable.

To view the complete clinical summary, click here.

MedLink Neurology authors are always at work to bring you broad and up-to-date coverage of neurology topics. We are pleased to highlight clinical summaries that have been recently added or updated and to introduce the authors who write these authoritative articles. We hope you enjoy these overviews and appreciate the contributions of our more than 450 authors who keep MedLink Neurology the premier information resource for neurologists.